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Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase

Sphingolipids (SLs) have been extensively investigated in biomedical research due to their role as bioactive molecules in cells. Here, we describe the effect of a SL analog, jaspine B (JB), a cyclic anhydrophytosphingosine found in marine sponges, on the gastric cancer cell line, HGC-27. JB induced...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Cingolani, Francesca, Simbari, Fabio, Abad, Jose Luis, Casasampere, Mireia, Fabrias, Gemma, Futerman, Anthony H., Casas, Josefina
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538274/
https://ncbi.nlm.nih.gov/pubmed/28572516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M072611
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