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Preclinical Evaluation of (11)C-Sarcosine as a Substrate of Proton-Coupled Amino Acid Transporters and First Human Application in Prostate Cancer
Sarcosine is a known substrate of proton-coupled amino acid transporters (PATs), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness an...
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| Izdano u: | J Nucl Med |
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| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Society of Nuclear Medicine
2017
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5537613/ https://ncbi.nlm.nih.gov/pubmed/28302759 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.173179 |
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