Preclinical Evaluation of (11)C-Sarcosine as a Substrate of Proton-Coupled Amino Acid Transporters and First Human Application in Prostate Cancer

Sarcosine is a known substrate of proton-coupled amino acid transporters (PATs), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness an...

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Vydáno v:J Nucl Med
Hlavní autoři: Piert, Morand, Shao, Xia, Raffel, David, Davenport, Mathew S., Montgomery, Jeffrey, Kunju, Lakshmi Priya, Hockley, Brian G., Siddiqui, Javed, Scott, Peter J.H., Chinnaiyan, Arul M., Rajendiran, Thekkelnaycke
Médium: Artigo
Jazyk:Inglês
Vydáno: Society of Nuclear Medicine 2017
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537613/
https://ncbi.nlm.nih.gov/pubmed/28302759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.116.173179
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