The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab

BACKGROUND: The data from randomised trials suggested that primary tumour sidedness could represent a prognostic and predictive factor in colorectal cancer (CRC) patients, particularly during treatment with anti-epidermal growth factor receptor (EGFR) therapy. However, an in-deep molecular selection...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Cancer
Prif Awduron: Demurtas, Laura, Puzzoni, Marco, Giampieri, Riccardo, Ziranu, Pina, Pusceddu, Valeria, Mandolesi, Alessandra, Cremolini, Chiara, Masi, Gianluca, Gelsomino, Fabio, Antoniotti, Carlotta, Loretelli, Cristian, Meriggi, Fausto, Zaniboni, Alberto, Falcone, Alfredo, Cascinu, Stefano, Scartozzi, Mario
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Clinical Study
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537494/
https://ncbi.nlm.nih.gov/pubmed/28632725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.178
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