The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild-type colorectal cancer patients receiving irinotecan/cetuximab

BACKGROUND: The data from randomised trials suggested that primary tumour sidedness could represent a prognostic and predictive factor in colorectal cancer (CRC) patients, particularly during treatment with anti-epidermal growth factor receptor (EGFR) therapy. However, an in-deep molecular selection...

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Vydáno v:Br J Cancer
Hlavní autoři: Demurtas, Laura, Puzzoni, Marco, Giampieri, Riccardo, Ziranu, Pina, Pusceddu, Valeria, Mandolesi, Alessandra, Cremolini, Chiara, Masi, Gianluca, Gelsomino, Fabio, Antoniotti, Carlotta, Loretelli, Cristian, Meriggi, Fausto, Zaniboni, Alberto, Falcone, Alfredo, Cascinu, Stefano, Scartozzi, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
Clinical Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537494/
https://ncbi.nlm.nih.gov/pubmed/28632725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.178
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