Epidermal Growth Factor Receptor (EGFR) gene copy number (GCN) correlates with clinical activity of irinotecan-cetuximab in K-RAS wild-type colorectal cancer: a fluorescence in situ (FISH) and chromogenic in situ hybridization (CISH) analysis

BACKGROUND: K-RAS wild type colorectal tumors show an improved response rate to anti-EGFR monoclonal antibodies. Nevertheless 70% to 40% of these patients still does not seem to benefit from this therapeutic approach. FISH EGFR GCN has been previously demonstrated to correlate with clinical outcome...

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Detalhes bibliográficos
Main Authors: Scartozzi, Mario, Bearzi, Italo, Mandolesi, Alessandra, Pierantoni, Chiara, Loupakis, Fotios, Zaniboni, Alberto, Negri, Francesca, Quadri, Antonello, Zorzi, Fausto, Galizia, Eva, Berardi, Rossana, Biscotti, Tommasina, Labianca, Roberto, Masi, Gianluca, Falcone, Alfredo, Cascinu, Stefano
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3087339/
https://ncbi.nlm.nih.gov/pubmed/19712476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-303
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