Astragaloside IV protects against podocyte injury via SERCA2-dependent ER stress reduction and AMPKα-regulated autophagy induction in streptozotocin-induced diabetic nephropathy

Aberrant endoplasmic reticulum (ER) stress and autophagy are associated with diabetic nephropathy. Here we investigated the effect of astragaloside IV (AS-IV) on the progression of diabetic nephropathy (DN) and the underlying mechanism involving ER stress and autophagy in streptozotocin (STZ)-induce...

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Опубликовано в: :Sci Rep
Главные авторы: Guo, Hengjiang, Wang, Yi, Zhang, Xuemei, Zang, Yingjun, Zhang, Yang, Wang, Li, Wang, Hao, Wang, Yunman, Cao, Aili, Peng, Wen
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537362/
https://ncbi.nlm.nih.gov/pubmed/28761152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07061-7
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