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Spatial structure of TLR4 transmembrane domain in bicelles provides the insight into the receptor activation mechanism
Toll-like receptors (TLRs) play a key role in the innate and adaptive immune systems. While a lot of structural data is available for the extracellular and cytoplasmic domains of TLRs, and a model of the dimeric full-length TLR3 receptor in the active state was build, the conformation of the transme...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5537299/ https://ncbi.nlm.nih.gov/pubmed/28761155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07250-4 |
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