Exendin-4 reduces food intake via the PI3K/AKT signaling pathway in the hypothalamus

Exendin-4 (EX-4), a glucagon-like peptide-1 (GLP-1) receptor agonist, has been shown to reduce food intake and to increase proopiomelanocortin (POMC) gene expression in the hypothalamus. In this study, we examined the potential neural mechanisms by which these effects occur. Male Sprague Dawley rats...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Yang, Yan, Choi, Pique P., Smith, Wanli W., Xu, Weijie, Ma, Delin, Cordner, Zachary A., Liang, Nu-Chu, Moran, Timothy H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537284/
https://ncbi.nlm.nih.gov/pubmed/28761132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06951-0
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