Enhanced MAPK signaling is essential for CSF3R induced leukemia

Both membrane-proximal and truncation mutations in CSF3R have recently been reported to drive the onset of chronic neutrophilic leukemia (CNL). Here we show that although truncation mutation alone can not induce leukemia, both proximal and compound mutations (proximal and truncation mutations on sam...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Rohrabaugh, Sara, Kesarwani, Meenu, Kincaid, Zachary, Huber, Erika, Leddonne, Jennifer, Siddiqui, Zain, Khalifa, Yara, Komurov, Kakajan, Grimes, H. Leighton, Azam, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5537052/
https://ncbi.nlm.nih.gov/pubmed/28031554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.376
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