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Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies
Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery...
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| Publicado no: | PLoS Genet |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5536394/ https://ncbi.nlm.nih.gov/pubmed/28715421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006916 |
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