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Statistical correction of the Winner’s Curse explains replication variability in quantitative trait genome-wide association studies

Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Genet
Egile Nagusiak: Palmer, Cameron, Pe’er, Itsik
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536394/
https://ncbi.nlm.nih.gov/pubmed/28715421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006916
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