G protein-coupled receptor kinase 2 promotes cardiac hypertrophy

The increase in protein activity and upregulation of G-protein coupled receptor kinase 2 (GRK2) is a hallmark of cardiac stress and heart failure. Inhibition of GRK2 improved cardiac function and survival and diminished cardiac remodeling in various animal heart failure models. The aim of the presen...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Schlegel, Philipp, Reinkober, Julia, Meinhardt, Eric, Tscheschner, Henrike, Gao, Erhe, Schumacher, Sarah M., Yuan, Ancai, Backs, Johannes, Most, Patrick, Wieland, Thomas, Koch, Walter J., Katus, Hugo A., Raake, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536362/
https://ncbi.nlm.nih.gov/pubmed/28759639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182110
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