AAV6.βARKct cardiac gene therapy ameliorates cardiac function and normalizes the catecholaminergic axis in a clinically relevant large animal heart failure model

AIMS: G protein-coupled receptor kinase 2 (GRK2), which is markedly upregulated in failing human myocardium, has been implicated as a contributing factor or consequence of heart failure (HF). Importantly, cardiac-specific GRK2 knockout mice have recently proved the pathological nature of GRK2 in HF....

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Detalhes bibliográficos
Main Authors: Raake, Philip W.J., Schlegel, Philipp, Ksienzyk, Jan, Reinkober, Julia, Barthelmes, Jens, Schinkel, Stefanie, Pleger, Sven, Mier, Walter, Haberkorn, Uwe, Koch, Walter J., Katus, Hugo A., Most, Patrick, Müller, Oliver J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653122/
https://ncbi.nlm.nih.gov/pubmed/22261894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehr447
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