Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit

On the basis of the recent atomic-resolution x-ray structure of the 50S ribosomal subunit, residues A2451 and G2447 of 23S rRNA were proposed to participate directly in ribosome-catalyzed peptide bond formation. We have examined the peptidyltransferase and protein synthesis activities of ribosomes c...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Thompson, Jill, Kim, Daniel F., O'Connor, Michael, Lieberman, Kate R., Bayfield, Mark A., Gregory, Steven T., Green, Rachel, Noller, Harry F., Dahlberg, Albert E.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2001
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55363/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11470897/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.151257098
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