Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion

Immature or semi-mature dendritic cells (DCs) represent tolerogenic maturation stages that can convert naive T cells into Foxp3(+) induced regulatory T cells (iTreg). Here we found that murine bone marrow-derived DCs (BM-DCs) treated with cholera toxin (CT) matured by up-regulating MHC-II and costim...

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Udgivet i:PLoS One
Main Authors: Silva-Vilches, Cinthia, Pletinckx, Katrien, Lohnert, Miriam, Pavlovic, Vladimir, Ashour, Diyaaeldin, John, Vini, Vendelova, Emilia, Kneitz, Susanne, Zhou, Jie, Chen, Rena, Reinheckel, Thomas, Mueller, Thomas D., Bodem, Jochen, Lutz, Manfred B.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536293/
https://ncbi.nlm.nih.gov/pubmed/28759565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0178114
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