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IL-12 from endogenous cDC1, and not vaccine DC, is required for Th1 induction

Success of DC vaccines relies on the quality of antigen presentation, costimulation, lymph node migration, and the release of IL-12, in case of Th1 priming. Here, we provide evidence for interaction between the injected vaccine DCs with endogenous lymph node–resident DCs for Th1 induction. While mig...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ashour, DiyaaElDin, Arampatzi, Panagiota, Pavlovic, Vladimir, Förstner, Konrad U., Kaisho, Tsuneyasu, Beilhack, Andreas, Erhard, Florian, Lutz, Manfred B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7259537/
https://ncbi.nlm.nih.gov/pubmed/32434994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135143
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