Imatinib Triggers Phagolysosome Acidification and Antimicrobial Activity against Mycobacterium bovis Bacille Calmette–Guérin in Glucocorticoid-Treated Human Macrophages

Glucocorticoids are extensively used to treat inflammatory diseases; however, their chronic intake increases the risk for mycobacterial infections. Meanwhile, the effects of glucocorticoids on innate host responses are incompletely understood. In this study, we investigated the direct effects of glu...

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Pubblicato in:J Immunol
Autori principali: Steiger, Julia, Stephan, Alexander, Inkeles, Megan S., Realegeno, Susan, Bruns, Heiko, Kröll, Philipp, de Castro Kroner, Juliana, Sommer, Andrea, Batinica, Marina, Pitzler, Lena, Kalscheuer, Rainer, Hartmann, Pia, Plum, Georg, Stenger, Steffen, Pellegrini, Matteo, Brachvogel, Bent, Modlin, Robert L., Fabri, Mario
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5536119/
https://ncbi.nlm.nih.gov/pubmed/27233968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502407
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