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mTORC2-IRF4 mediated metabolic reprograming is essential for macrophage alternative activation

Changes in metabolism can be initiated in response to signals received from other cells. An example of this is provided by macrophages that have been stimulated by IL-4 to become alternatively/M2 activated. In these cells, fatty acid oxidation is increased and this is critical for M2 activation. Com...

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Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Huang, Stanley Ching-Cheng, Smith, Amber M., Everts, Bart, Colonna, Marco, Pearce, Erika L., Schilling, Joel D., Pearce, Edward J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5535820/
https://ncbi.nlm.nih.gov/pubmed/27760338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.09.016
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