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NLRC3 protein inhibits inflammation by disrupting NALP3 inflammasome assembly via competition with the adaptor protein ASC for pro-caspase-1 binding
Inflammasomes are multiprotein complexes that sense pathogen-associated and danger-associated molecular patterns and induce inflammation in cells. The NALP3 inflammasome is tightly regulated by recently discovered control mechanisms, but other modulators still remain to be characterized. NLR family...
Wedi'i Gadw mewn:
Cyhoeddwyd yn: | J Biol Chem |
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Prif Awduron: | , , |
Fformat: | Artigo |
Iaith: | Inglês |
Cyhoeddwyd: |
American Society for Biochemistry and Molecular Biology
2017
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Pynciau: | |
Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5535042/ https://ncbi.nlm.nih.gov/pubmed/28584053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.769695 |
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