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Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase

OBJECTIVE: In order to explain the increased susceptibility to serious infection in alcoholic hepatitis, we evaluated monocyte phagocytosis, aberrations of associated signalling pathways and their reversibility, and whether phagocytic defects could predict subsequent infection. DESIGN: Monocytes wer...

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Detalhes bibliográficos
Publicado no:Gut
Main Authors: Vergis, Nikhil, Khamri, Wafa, Beale, Kylie, Sadiq, Fouzia, Aletrari, Mina O, Moore, Celia, Atkinson, Stephen R, Bernsmeier, Christine, Possamai, Lucia A, Petts, Gemma, Ryan, Jennifer M, Abeles, Robin D, James, Sarah, Foxton, Matthew, Hogan, Brian, Foster, Graham R, O'Brien, Alastair J, Ma, Yun, Shawcross, Debbie L, Wendon, Julia A, Antoniades, Charalambos G, Thursz, Mark R
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534772/
https://ncbi.nlm.nih.gov/pubmed/26860769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2015-310378
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