Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

OBJECTIVE: The generation of acinar and ductal cells from human pluripotent stem cells (PSCs) is a poorly studied process, although various diseases arise from this compartment. DESIGN: We designed a straightforward approach to direct human PSCs towards pancreatic organoids resembling acinar and duc...

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Veröffentlicht in:Gut
Hauptverfasser: Hohwieler, Meike, Illing, Anett, Hermann, Patrick C, Mayer, Tobias, Stockmann, Marianne, Perkhofer, Lukas, Eiseler, Tim, Antony, Justin S, Müller, Martin, Renz, Susanne, Kuo, Chao-Chung, Lin, Qiong, Sendler, Matthias, Breunig, Markus, Kleiderman, Susanne M, Lechel, André, Zenker, Martin, Leichsenring, Michael, Rosendahl, Jonas, Zenke, Martin, Sainz, Bruno, Mayerle, Julia, Costa, Ivan G, Seufferlein, Thomas, Kormann, Michael, Wagner, Martin, Liebau, Stefan, Kleger, Alexander
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2017
Schlagworte:
Pancreas
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534761/
https://ncbi.nlm.nih.gov/pubmed/27633923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-312423
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