Endothelial Notch signalling limits angiogenesis via control of artery formation

Angiogenic sprouting needs to be tightly controlled. It has been suggested that the Notch ligand dll4 expressed in leading tip cells restricts angiogenesis by activating Notch signalling in trailing stalk cells. Here, we show using live imaging in zebrafish that activation of Notch signalling is rat...

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Udgivet i:Nat Cell Biol
Main Authors: Hasan, Sana S., Tsaryk, Roman, Lange, Martin, Wisniewski, Laura, Moore, John C., Lawson, Nathan D., Wojciechowska, Karolina, Schnittler, Hans, Siekmann, Arndt F.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534340/
https://ncbi.nlm.nih.gov/pubmed/28714969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3574
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