Covalent Linkage of HIV-1 Trimers to Synthetic Liposomes Elicits Improved B Cell and Antibody Responses

We have demonstrated that a liposomal array of well-ordered trimers enhances B cell activation, germinal center formation, and the elicitation of tier-2 autologous neutralizing antibodies. Previously, we coupled well-ordered cleavage-independent NFL trimers via their C-terminal polyhistidine tails t...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Bale, Shridhar, Goebrecht, Geraldine, Stano, Armando, Wilson, Richard, Ota, Takayuki, Tran, Karen, Ingale, Jidnyasa, Zwick, Michael B., Wyatt, Richard T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533919/
https://ncbi.nlm.nih.gov/pubmed/28592540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00443-17
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