Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1

The bifunctional protein kinase-endoribonuclease Ire1 initiates splicing of the mRNA for the transcription factor Hac1 when unfolded proteins accumulate in the endoplasmic reticulum. Activation of Saccharomyces cerevisiae Ire1 coincides with autophosphorylation of its activation loop at S840, S841,...

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Pubblicato in:Mol Cell Biol
Autori principali: Armstrong, Michael C., Šestak, Sergej, Ali, Ahmed A., Sagini, Hanan A. M., Brown, Max, Baty, Karen, Treumann, Achim, Schröder, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533888/
https://ncbi.nlm.nih.gov/pubmed/28559428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00655-16
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