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Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds
PURPOSE: To develop a small-scale set-up to rapidly and accurately determine the intrinsic dissolution rate (IDR) and apparent solubility of poorly water-soluble compounds. METHODS: The IDR and apparent solubility (S(app)) were measured in fasted state simulated intestinal fluid (FaSSIF) for six mod...
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| Publicat a: | Pharm Res |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Springer US
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5533823/ https://ncbi.nlm.nih.gov/pubmed/28620887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2188-1 |
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