Controlled Suspensions Enable Rapid Determinations of Intrinsic Dissolution Rate and Apparent Solubility of Poorly Water-Soluble Compounds

PURPOSE: To develop a small-scale set-up to rapidly and accurately determine the intrinsic dissolution rate (IDR) and apparent solubility of poorly water-soluble compounds. METHODS: The IDR and apparent solubility (S(app)) were measured in fasted state simulated intestinal fluid (FaSSIF) for six mod...

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Udgivet i:Pharm Res
Main Authors: Andersson, Sara B. E., Alvebratt, Caroline, Bergström, Christel A. S.
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533823/
https://ncbi.nlm.nih.gov/pubmed/28620887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-017-2188-1
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