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Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy

Fuchs endothelial corneal dystrophy (FECD) is a slowly progressive bilateral disease of corneal endothelium in which accumulation of extracellular matrix (ECM) and loss of corneal endothelial cells (CECs) are phenotypic features. The corneal endothelium maintains corneal transparency by regulating w...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Okumura, Naoki, Hashimoto, Keisuke, Kitahara, Miu, Okuda, Hirokazu, Ueda, Emi, Watanabe, Kyoko, Nakahara, Makiko, Sato, Takahiko, Kinoshita, Shigeru, Tourtas, Theofilos, Schlötzer-Schrehardt, Ursula, Kruse, Friedrich, Koizumi, Noriko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533742/
https://ncbi.nlm.nih.gov/pubmed/28754918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06924-3
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