Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development

Neural tube defects (NTDs) are prevalent human birth defects. Mitogen-activated protein kinases (MAPKs), such as c-Jun N-terminal kinase (JNK), are implicated in facilitating neural tube closure, yet upstream regulators remain to be identified. Here, we show that MAP kinase kinase kinase 4 (MEKK4) i...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chi, Hongbo, Sarkisian, Matthew R., Rakic, Pasko, Flavell, Richard A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC553336/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15731347/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500026102
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