MEKK4 Signaling Regulates Filamin Expression and Neuronal Migration

Periventricular heterotopia (PVH) is a congenital malformation of human cerebral cortex frequently associated with Filamin-A (FLN-A) mutations but the pathogenetic mechanisms remain unclear. Here we show that the MEKK4 (MAP3K4) pathway is involved in Fln-A regulation and PVH formation. MEKK4−/− mice...

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Hlavní autoři: Sarkisian, Matthew R., Bartley, Christopher M., Chi, Hongbo, Nakamura, Fumihiko, Hashimoto-Torii, Kazue, Torii, Masaaki, Flavell, Richard A., Rakic, Pasko
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876745/
https://ncbi.nlm.nih.gov/pubmed/17145501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2006.10.024
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