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Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering
Residues important in the interaction between the 23-residue transmembrane (TM) domains of the integrin α(IIb)- and β(3)-subunits were identified by mutating each non-Leu residue to Leu. Leu substitutions of α(IIb) at G972, G976, and T981, and of β(3) at I693 and G708, increased ligand binding. Subs...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC553322/ https://ncbi.nlm.nih.gov/pubmed/15738420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409440102 |
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