Načítá se...
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering
Residues important in the interaction between the 23-residue transmembrane (TM) domains of the integrin α(IIb)- and β(3)-subunits were identified by mutating each non-Leu residue to Leu. Leu substitutions of α(IIb) at G972, G976, and T981, and of β(3) at I693 and G708, increased ligand binding. Subs...
Uloženo v:
| Hlavní autoři: | , , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2005
|
| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC553322/ https://ncbi.nlm.nih.gov/pubmed/15738420 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409440102 |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!
|