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Ion mobility spectrometry combined with ultra performance liquid chromatography/mass spectrometry for metabolic phenotyping of urine: Effects of column length, gradient duration and ion mobility spectrometry on metabolite detection

The need for rapid and efficient high throughput metabolic phenotyping (metabotyping) in metabolomic/metabonomic studies often requires compromises to be made between analytical speed and metabolome coverage. Here the effect of column length (150, 75 and 30 mm) and gradient duration (15, 7.5 and 3 m...

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Publicat a:Anal Chim Acta
Autors principals: Rainville, Paul D., Wilson, Ian D., Nicholson, Jeremy K., Issacs, Giorgis, Mullin, Lauren, Langridge, James I., Plumb, Robert S.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533171/
https://ncbi.nlm.nih.gov/pubmed/28734348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2017.06.020
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