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Ion mobility spectrometry combined with ultra performance liquid chromatography/mass spectrometry for metabolic phenotyping of urine: Effects of column length, gradient duration and ion mobility spectrometry on metabolite detection

The need for rapid and efficient high throughput metabolic phenotyping (metabotyping) in metabolomic/metabonomic studies often requires compromises to be made between analytical speed and metabolome coverage. Here the effect of column length (150, 75 and 30 mm) and gradient duration (15, 7.5 and 3 m...

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Detalles Bibliográficos
Publicado en:Anal Chim Acta
Main Authors: Rainville, Paul D., Wilson, Ian D., Nicholson, Jeremy K., Issacs, Giorgis, Mullin, Lauren, Langridge, James I., Plumb, Robert S.
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533171/
https://ncbi.nlm.nih.gov/pubmed/28734348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.aca.2017.06.020
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