Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure

BACKGROUND: The significance of brain angiotensin II in Alzheimer disease (AD) is unclear. METHODS AND RESULTS: To examine the role of brain angiotensin II in AD, intracerebroventricular angiotensin II infusion was performed on 5XFAD mice, a mouse model of AD, and wild‐type mice, and the detrimental...

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Pubblicato in:J Am Heart Assoc
Autori principali: Takane, Koki, Hasegawa, Yu, Lin, Bowen, Koibuchi, Nobutaka, Cao, Cheng, Yokoo, Takashi, Kim‐Mitsuyama, Shokei
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2017
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533006/
https://ncbi.nlm.nih.gov/pubmed/28428194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.116.004897
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