DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

BACKGROUND: It is unclear whether dipeptidylpeptidase-4 (DPP-4) inhibition can counteract the impairment of cognitive function and brain injury caused by transient cerebral ischemia in type 2 diabetes. The present study was undertaken to test our hypothesis that linagliptin, a DPP-4 inhibitor, admin...

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Detalhes bibliográficos
Publicado no:Cardiovasc Diabetol
Main Authors: Ma, MingJie, Hasegawa, Yu, Koibuchi, Nobutaka, Toyama, Kensuke, Uekawa, Ken, Nakagawa, Takashi, Lin, Bowen, Kim-Mitsuyama, Shokei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Original Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458052/
https://ncbi.nlm.nih.gov/pubmed/25986579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12933-015-0218-z
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