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Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells
A method to genetically program mouse hematopoietic stem cells to develop into functional CD8 or CD4 T cells of defined specificity in vivo is described. For this purpose, a bicistronic retroviral vector was engineered that efficiently delivers genes for both α and β chains of T cell receptor (TCR)...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC553287/ https://ncbi.nlm.nih.gov/pubmed/15758071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500600102 |
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