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Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G

Pathogenesis in aquaporin-4 immunoglobulin G (AQP4-IgG) seropositive neuromyelitis optica spectrum disorders (herein called NMO) involves complement-dependent cytotoxicity initiated by AQP4-IgG binding to astrocyte AQP4. We recently reported that rats lacking complement inhibitor protein CD59 were h...

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Bibliografiske detaljer
Udgivet i:Acta Neuropathol Commun
Main Authors: Yao, Xiaoming, Verkman, Alan S.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532786/
https://ncbi.nlm.nih.gov/pubmed/28750658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0462-4
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