Chemotherapy-induced gastrointestinal toxicity is associated with changes in serum and urine metabolome and fecal microbiota in male Sprague–Dawley rats

PURPOSE: Chemotherapy-induced gastrointestinal toxicity (CIGT) is a complex process that involves multiple pathophysiological mechanisms. We have previously shown that commonly used chemotherapeutics 5-fluorouracil, oxaliplatin, and irinotecan damage the intestinal mucosa and increase intestinal per...

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Bibliographic Details
Published in:Cancer Chemother Pharmacol
Main Authors: Forsgård, Richard A., Marrachelli, Vannina G., Korpela, Katri, Frias, Rafael, Collado, Maria Carmen, Korpela, Riitta, Monleon, Daniel, Spillmann, Thomas, Österlund, Pia
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532424/
https://ncbi.nlm.nih.gov/pubmed/28646338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3364-z
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