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Eribulin shows high concentration and long retention in xenograft tumor tissues
PURPOSE: Eribulin, a synthetic analog of the natural product halichondrin B, is a microtubule dynamics inhibitor. In this study, we report the pharmacokinetic profiles of eribulin in mice, rats, and dogs following intravenous administrations with optimized and validated bio-analytical methods. METHO...
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| Publicado en: | Cancer Chemother Pharmacol |
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| Autores principales: | , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Springer Berlin Heidelberg
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5532402/ https://ncbi.nlm.nih.gov/pubmed/28664226 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3369-7 |
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