CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells

Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release are poorly understood. CALHM1, a transmembrane protein with shared structural features to...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Workman, Alan D., Carey, Ryan M., Chen, Bei, Saunders, Cecil J., Marambaud, Philippe, Mitchell, Claire H., Tordoff, Michael G., Lee, Robert J., Cohen, Noam A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532211/
https://ncbi.nlm.nih.gov/pubmed/28751666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07221-9
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