CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells

Mechanical stimulation of airway epithelial cells causes apical release of ATP, which increases ciliary beat frequency (CBF) and speeds up mucociliary clearance. The mechanisms responsible for this ATP release are poorly understood. CALHM1, a transmembrane protein with shared structural features to...

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Udgivet i:Sci Rep
Main Authors: Workman, Alan D., Carey, Ryan M., Chen, Bei, Saunders, Cecil J., Marambaud, Philippe, Mitchell, Claire H., Tordoff, Michael G., Lee, Robert J., Cohen, Noam A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532211/
https://ncbi.nlm.nih.gov/pubmed/28751666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07221-9
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