Deletion of Endothelial Cell-Specific Liver Kinase B1 Increases Angiogenesis and Tumor Growth via Vascular Endothelial Growth Factor

Liver kinase B1 (LKB1) is a serine/threonine protein kinase ubiquitously expressed in mammalian cells. It was first identified in Peutz-Jeghers syndrome as a tumor suppressor gene. Whether endothelial LKB1 regulates angiogenesis and tumor growth is unknown. In this study, we generated endothelial ce...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Zhang, Wencheng, Ding, Ye, Zhang, Cheng, Lu, Qiulun, Liu, Zhaoyu, Coughlan, Kathleen, Okon, Imoh, Zou, Ming-Hui
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532072/
https://ncbi.nlm.nih.gov/pubmed/28346429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.61
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