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Dissection of specific binding of HIV-1 Gag to the 'packaging signal' in viral RNA

Selective packaging of HIV-1 genomic RNA (gRNA) requires the presence of a cis-acting RNA element called the ‘packaging signal’ (Ψ). However, the mechanism by which Ψ promotes selective packaging of the gRNA is not well understood. We used fluorescence correlation spectroscopy and quenching data to...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Comas-Garcia, Mauricio, Datta, Siddhartha AK, Baker, Laura, Varma, Rajat, Gudla, Prabhakar R, Rein, Alan
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531834/
https://ncbi.nlm.nih.gov/pubmed/28726630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.27055
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