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Host genetics play a critical role in controlling CD8 T cell function and lethal immunopathology during chronic viral infection

Effective CD8 T cell responses are vital for the control of chronic viral infections. Many factors of the host immune response contribute to the maintenance of effector CD8 T cell responses versus CD8 T cell exhaustion during chronic infection. Specific MHC alleles and the degree of MHC heterogeneit...

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Udgivet i:PLoS Pathog
Main Authors: Christiaansen, Allison F., Schmidt, Megan E., Hartwig, Stacey M., Varga, Steven M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531689/
https://ncbi.nlm.nih.gov/pubmed/28715493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006498
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