Low levels of the AhR in chronic obstructive pulmonary disease (COPD)-derived lung cells increases COX-2 protein by altering mRNA stability

Heightened inflammation, including expression of COX-2, is associated with chronic obstructive pulmonary disease (COPD) pathogenesis. The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is reduced in COPD-derived lung fibroblasts. The AhR also suppresses COX-2 in resp...

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Bibliographic Details
Published in:PLoS One
Main Authors: Zago, Michela, Sheridan, Jared A., Traboulsi, Hussein, Hecht, Emelia, Zhang, Yelu, Guerrina, Necola, Matthews, Jason, Nair, Parameswaran, Eidelman, David H., Hamid, Qutayba, Baglole, Carolyn J.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531650/
https://ncbi.nlm.nih.gov/pubmed/28749959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180881
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