Decreased expression of the NF-κB family member RelB in lung fibroblasts from Smokers with and without COPD potentiates cigarette smoke-induced COX-2 expression

BACKGROUND: Heightened inflammation, including expression of COX-2, is associated with COPD pathogenesis. RelB is an NF-κB family member that attenuates COX-2 in response to cigarette smoke by a mechanism that may involve the miRNA miR-146a. There is no information on the expression of RelB in COPD...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Sheridan, Jared A, Zago, Michela, Nair, Parameswaran, Li, Pei Z, Bourbeau, Jean, Tan, Wan C, Hamid, Qutayba, Eidelman, David H, Benedetti, Andrea L, Baglole, Carolyn J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427974/
https://ncbi.nlm.nih.gov/pubmed/25943190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0214-6
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