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Prediction of novel target genes and pathways involved in irinotecan-resistant colorectal cancer

BACKGROUND: Acquired drug resistance to the chemotherapeutic drug irinotecan (the active metabolite of which is SN-38) is one of the significant obstacles in the treatment of advanced colorectal cancer (CRC). The molecular mechanism or targets mediating irinotecan resistance are still unclear. It is...

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Bibliografski detalji
Izdano u:PLoS One
Glavni autori: Makondi, Precious Takondwa, Chu, Chi-Ming, Wei, Po-Li, Chang, Yu-Jia
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531462/
https://ncbi.nlm.nih.gov/pubmed/28749961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180616
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