DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes

Loss of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity in mammals results in severe combined immuno-deficiency (SCID). This SCID phenotype has been postulated to be due solely to the function of DNA-PKcs in V(D)J recombination, a process critical for lymphocyte maturation. Howeve...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim Wiese, Ara, Schluterman Burdine, Marie, Turnage, Richard H., Tackett, Alan J., Burdine, Lyle J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531461/
https://ncbi.nlm.nih.gov/pubmed/28750002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181608
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