Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely understood. Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its ro...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Wang, Ya-Ting, Chen, Jocelyn, Chang, Chou-Wei, Jen, Jayu, Huang, Tzu-Yu, Chen, Chun-Ming, Shen, Roger, Liang, Suh-Yuen, Cheng, I-Cheng, Yang, Shuenn-Chen, Lai, Wu-Wei, Cheng, Kuang-Hung, Hsieh, Tao-Shih, Lai, Ming-Zong, Cheng, Hung-Chi, Wang, Yi-Ching, Chen, Ruey-Hwa
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531412/
https://ncbi.nlm.nih.gov/pubmed/28691927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89957
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