Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely understood. Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its ro...

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Foilsithe in:J Clin Invest
Main Authors: Wang, Ya-Ting, Chen, Jocelyn, Chang, Chou-Wei, Jen, Jayu, Huang, Tzu-Yu, Chen, Chun-Ming, Shen, Roger, Liang, Suh-Yuen, Cheng, I-Cheng, Yang, Shuenn-Chen, Lai, Wu-Wei, Cheng, Kuang-Hung, Hsieh, Tao-Shih, Lai, Ming-Zong, Cheng, Hung-Chi, Wang, Yi-Ching, Chen, Ruey-Hwa
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Clinical Investigation 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531412/
https://ncbi.nlm.nih.gov/pubmed/28691927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89957
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