Ubiquitination of tumor suppressor PML regulates prometastatic and immunosuppressive tumor microenvironment

The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely understood. Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its ro...

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Publicado en:J Clin Invest
Autores principales: Wang, Ya-Ting, Chen, Jocelyn, Chang, Chou-Wei, Jen, Jayu, Huang, Tzu-Yu, Chen, Chun-Ming, Shen, Roger, Liang, Suh-Yuen, Cheng, I-Cheng, Yang, Shuenn-Chen, Lai, Wu-Wei, Cheng, Kuang-Hung, Hsieh, Tao-Shih, Lai, Ming-Zong, Cheng, Hung-Chi, Wang, Yi-Ching, Chen, Ruey-Hwa
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531412/
https://ncbi.nlm.nih.gov/pubmed/28691927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89957
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