Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2

Accumulating evidence suggests that glioma stem cells (GSCs) are important therapeutic targets in glioblastoma (GBM). In this study, we identified NIMA-related kinase 2 (NEK2) as a functional binding protein of enhancer of zeste homolog 2 (EZH2) that plays a critical role in the posttranslational re...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Wang, Jia, Cheng, Peng, Pavlyukov, Marat S., Yu, Hai, Zhang, Zhuo, Kim, Sung-Hak, Minata, Mutsuko, Mohyeldin, Ahmed, Xie, Wanfu, Chen, Dongquan, Goidts, Violaine, Frett, Brendan, Hu, Wenhao, Li, Hongyu, Shin, Yong Jae, Lee, Yeri, Nam, Do-Hyun, Kornblum, Harley I., Wang, Maode, Nakano, Ichiro
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531394/
https://ncbi.nlm.nih.gov/pubmed/28737508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89092
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