Targeting NEK2 attenuates glioblastoma growth and radioresistance by destabilizing histone methyltransferase EZH2

Accumulating evidence suggests that glioma stem cells (GSCs) are important therapeutic targets in glioblastoma (GBM). In this study, we identified NIMA-related kinase 2 (NEK2) as a functional binding protein of enhancer of zeste homolog 2 (EZH2) that plays a critical role in the posttranslational re...

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書誌詳細
出版年:J Clin Invest
主要な著者: Wang, Jia, Cheng, Peng, Pavlyukov, Marat S., Yu, Hai, Zhang, Zhuo, Kim, Sung-Hak, Minata, Mutsuko, Mohyeldin, Ahmed, Xie, Wanfu, Chen, Dongquan, Goidts, Violaine, Frett, Brendan, Hu, Wenhao, Li, Hongyu, Shin, Yong Jae, Lee, Yeri, Nam, Do-Hyun, Kornblum, Harley I., Wang, Maode, Nakano, Ichiro
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2017
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531394/
https://ncbi.nlm.nih.gov/pubmed/28737508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI89092
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